I2C lines are permanently low without any active external device

I2C lines are permanently low without any active external device and the I2C lines are high if Optii is not connected?
Please check this:

  • Are both sides powered with a voltage between 1.5 V and 5.5 V?
  • Do both buses deliver the required supply current?
  • Is the pinning of the cables correct?
  • Are the connectors plugged in correctly?